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Senior Scientist, Protein Sciences

February 24, 2026

<h3>The Position</h3>A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!The OpportunityThe Department of Protein Sciences at Genentech has an exciting opportunity for a Senior Scientist with a strong background in protein biochemistry and structural biology to join our Structural Biology and Protein Engineering groups.In this role, you will act as a technical expert responsible for the production of high-quality protein reagents in support of small molecule, peptide and antibody drug discovery campaigns. You will support hit finding efforts such as high-throughput screening, DNA-encoded library technologies, or display-based selections and deliver high-resolution ligand-protein structures in support of lead molecule optimization. Additionally, you will investigate, institute, and develop methods to improve the tractability of challenging proteins and identify, evaluate and implement new technology opportunities to accelerate and scale protein production.A proven track record in optimizing the expression and purification of challenging proteins for functional and structural studies is essential. Hands-on experience using different purification and reconstitution approaches and biochemical/structural characterization of membrane proteins and membrane-associated protein complexes from recombinant or endogenous sources is highly desirable.In addition to expertise in protein biochemistry, you will employ biochemical, biophysical, and computational methods to support structure-based drug design, antibody discovery, protein engineering approaches, and you will elucidate function and mechanism of action through high-resolution structural analyses. Accordingly, proficiency in X-ray crystallography and/or cryo-EM methods and a passion for exploring the structural basis of protein-protein and protein-ligand interactions is essential.The successful candidate will be a technical expert who can lead from the bench and collaborate fruitfully with colleagues on multiple interdepartmental project teams. Overall, you will be an outstanding biochemist, structural biologist and collaborator who will have a significant impact on our portfolio, with the unique opportunity to help drive discovery projects from inception to early development.Who You AreRequired Qualifications:<ul><li>Education: Ph.D. in biochemistry, biophysics, protein engineering, and/or structural biology.</li><li>Experience: 0-3 years post-Ph.D. experience. While early postdoctoral or industry experience is desirable, it is not strictly required for candidates with an outstanding scholastic record and technical proficiency.</li><li>Technical Expertise: Experience with multiple protein targets is required.</li><li>Track Record: Productive pre-doctoral training reflected in an established track record of high-impact publications or patents. You should demonstrate a strong prospect for independent thought and creativity in the development and application of mission-critical technology.</li></ul>Additional Qualifications & Responsibilities:<ul><li>Scientific Independence: Ability to plan, design, and execute experiments within the context of department or project goals, maintaining necessary scientific records and drawing sound conclusions.</li><li>Protein Production: Hands-on experience engineering and optimizing the production of challenging protein targets to generate and characterize milligram quantities of high-quality protein reagents.</li><li>Communication: Excellent communication, interpersonal, and organizational skills.</li><li>Attitude: A fearless attitude to tackle longstanding difficult problems.</li></ul>Preferred<ul><li>Membrane protein experience on GPCRs, ion channels, and/or transporters is highly desirable.</li><li>Experience with biophysical/biochemical assays to characterize protein conformation is a plus.</li><li></li></ul>Relocation benefits are available for this posting.The expected salary range for this position based on the primary location of California is $124,300 to $230,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.<a href="" target="_blank">Benefits</a>#LI-KC2Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form <a target="_blank" href="">Accommodations for Applicants</a>.

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Common Interview Questions And Answers

1. HOW DO YOU PLAN YOUR DAY?

This is what this question poses: When do you focus and start working seriously? What are the hours you work optimally? Are you a night owl? A morning bird? Remote teams can be made up of people working on different shifts and around the world, so you won't necessarily be stuck in the 9-5 schedule if it's not for you...

2. HOW DO YOU USE THE DIFFERENT COMMUNICATION TOOLS IN DIFFERENT SITUATIONS?

When you're working on a remote team, there's no way to chat in the hallway between meetings or catch up on the latest project during an office carpool. Therefore, virtual communication will be absolutely essential to get your work done...

3. WHAT IS "WORKING REMOTE" REALLY FOR YOU?

Many people want to work remotely because of the flexibility it allows. You can work anywhere and at any time of the day...

4. WHAT DO YOU NEED IN YOUR PHYSICAL WORKSPACE TO SUCCEED IN YOUR WORK?

With this question, companies are looking to see what equipment they may need to provide you with and to verify how aware you are of what remote working could mean for you physically and logistically...

5. HOW DO YOU PROCESS INFORMATION?

Several years ago, I was working in a team to plan a big event. My supervisor made us all work as a team before the big day. One of our activities has been to find out how each of us processes information...

6. HOW DO YOU MANAGE THE CALENDAR AND THE PROGRAM? WHICH APPLICATIONS / SYSTEM DO YOU USE?

Or you may receive even more specific questions, such as: What's on your calendar? Do you plan blocks of time to do certain types of work? Do you have an open calendar that everyone can see?...

7. HOW DO YOU ORGANIZE FILES, LINKS, AND TABS ON YOUR COMPUTER?

Just like your schedule, how you track files and other information is very important. After all, everything is digital!...

8. HOW TO PRIORITIZE WORK?

The day I watched Marie Forleo's film separating the important from the urgent, my life changed. Not all remote jobs start fast, but most of them are...

9. HOW DO YOU PREPARE FOR A MEETING AND PREPARE A MEETING? WHAT DO YOU SEE HAPPENING DURING THE MEETING?

Just as communication is essential when working remotely, so is organization. Because you won't have those opportunities in the elevator or a casual conversation in the lunchroom, you should take advantage of the little time you have in a video or phone conference...

10. HOW DO YOU USE TECHNOLOGY ON A DAILY BASIS, IN YOUR WORK AND FOR YOUR PLEASURE?

This is a great question because it shows your comfort level with technology, which is very important for a remote worker because you will be working with technology over time...